Certified Diabetes Care and Education Specialist (CDCES) Practice Exam

Which medication is most helpful in promoting weight loss for patients with diabetes?

1. Pioglitazone

2. Semaglutide

3. Sitagliptin

4. Insulin Glargine

The correct answer is: Semaglutide

Semaglutide is recognized for its efficacy in promoting weight loss among patients with diabetes. This medication is a glucagon-like peptide-1 (GLP-1) receptor agonist, which not only aids in glycemic control but also influences appetite regulation and food intake. The mechanism involves slowing gastric emptying and enhancing satiety, which can lead to a significant reduction in body weight. Patients using semaglutide often report a decrease in cravings and an improved ability to manage their diet, both of which contribute to overall weight loss. Research and clinical studies have supported these benefits, showcasing that as patients achieve better blood sugar control, they also experience notable weight reductions, making semaglutide a valuable option in diabetes management for those struggling with obesity. In contrast, other options, like Pioglitazone, Sitagliptin, and Insulin Glargine, do not primarily serve the purpose of weight loss in patients with diabetes. Pioglitazone is associated with weight gain due to fat accumulation, while Sitagliptin has a neutral effect on weight. Insulin Glargine can lead to weight gain as well, primarily due to improved glucose utilization and an increase in calorie storage. Thus, semaglutide stands