Certified Diabetes Care and Education Specialist (CDCES) Practice Exam

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Which diabetes medication is NOT recommended for breastfeeding women?

Glipizide
Metformin
Acarbose
Sitagliptin

The correct answer is: Sitagliptin

Sitagliptin is not recommended for breastfeeding women primarily because there is limited data on its safety during lactation. While some anti-diabetic medications have established records of safe use in breastfeeding, sitagliptin's effects on breast milk composition and potential impact on a nursing infant have not been fully studied, thus presenting uncertainty regarding its use in this population. In contrast, medications such as metformin and glipizide have shown some safe usage during breastfeeding, with metformin being frequently prescribed to lactating mothers as it passes into breast milk in minimal amounts and is generally considered safe. Similarly, acarbose is minimally absorbed and has not demonstrated adverse effects in breastfeeding, making it a safer option as well. This distinction underscores the importance of evaluating the available evidence related to specific medications and their compatibility with breastfeeding to ensure both maternal and infant safety.