Certified Diabetes Care and Education Specialist (CDCES) Practice Exam

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Prepare for the Certified Diabetes Care and Education Specialist Test. Utilize flashcards, multiple choice questions with hints, and detailed explanations. Get exam-ready!

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Which class of diabetes medications is generally contraindicated for patients with congestive heart failure (CHF)?

DPP-4 inhibitors
Thiazolidinediones (TZDs)
Sulfonylureas
GLP-1 receptor antagonists

The correct answer is: Thiazolidinediones (TZDs)

Thiazolidinediones (TZDs) are generally contraindicated for patients with congestive heart failure (CHF) primarily due to their potential to cause fluid retention. This class of medications acts as agonists of peroxisome proliferator-activated receptor gamma (PPAR-γ), which can lead to increased adipose tissue and fluid retention. In patients with CHF, additional fluid accumulation can exacerbate their condition, leading to increased morbidity and potentially worsening heart failure symptoms. In contrast, the other classes of medications listed have different mechanisms of action and do not carry the same risk of promoting fluid retention. DPP-4 inhibitors and GLP-1 receptor agonists are generally considered safer options for patients with CHF, as they do not significantly affect fluid balance. Sulfonylureas do not specifically contraindicate for CHF but should be used with caution due to their potential for hypoglycemia, which can also stress cardiovascular function. Thus, TZDs stand out as a contraindicated choice for patients with CHF due to their direct impact on fluid retention, making them inappropriate for this patient population.